If you put these off until your last and final playthrough, if they were to glitch then you will be fooling yourself into doing another playthrough so try to get them in your first runthrough and then if they do glitch, you have your 2nd playthrough to fall back on.
There is a reasoning to why I suggest targeting these trophies for your first playthrough, that is because these 4 golds have a small risk of glitching. If played stealthily then it is realistic to get all of these trophies in one playthrough so the style of play, use of Backup saves, sticky shockers and air foils should not put you of in targeting the game's hardest trophies. In doing so, you will earn yourself: Phantom Strike, Samaritian, Immune, Five-seveN, Ghosts don't die and Sleep Overs. Throughout playthrough, ensure that you complete it without: dying, raising an alarm, using Medkits and firing your assault rifle.
Start a New Game and complete it in it's entirety under Normal Mode for Mission Complete. Step 1: Full Playthrough (Normal Difficulty)
